A REVIEW ON TOPICAL OPHTHALMIC DRUG DELIVERY SYSTEMS

Oil in water emulsion is useful for delivery of Water insoluble drugs, which is solubilised in the internal oil phase. 6.  Colloidal part Iles:   The potential use of polymeric colloidal particles as ophthalmic drug delivery systems started in late 1970's.The first two systems studied in this area were pilocarpine cellulose acetate hydrogen phthalate latex systems and piloplex. But both the system could not enter commercial development because of various issues, like local toxicity, non-biodegradable polymer and large scale sterilization. 7.  Liposomes :   The use of liposomes as a topically administered ocu­lar drug delivery system began in the early stage of re­search into ophthalmic drug delivery. But the results were favorable for lipophilic drugs and not for-hydrophilic drugs. It was concluded that liposomes must be suitable for ocular drug delivery, provided, they had an affinity for, and were able to bind to, ocular surfaces, and release contents at optimal rates22. Positively charged liposomes have a greater affinity, to increase both precorneal drug retention and drug bioavailability .The addition of stearylamine to a liposomal preparation enhanced the corneal absorption of dexamethyl valerate. The corneal epithelium is thinly coated with nega­tively charged mucin to which the positive surface charge of the liposome may absorb more strongly. Coating with bioadhesive polymers to liposomes, prolong the precomea retention of liposomes. Carbopol 1342-coated pilocarpine23 containing liposomes were shown to produce a longer du­ration of action.

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