A REVIEW ON TOPICAL OPHTHALMIC DRUG DELIVERY SYSTEMS
Gelrite Is a polysaccharide (gellen gum), which forms a clear gel in the presence of mono or divalent cation. The high viscosity of the gel, however, results in blurring of vision and malted eyelids which substantially reduce patient acceptability. Sterilization is another drawback for large-scale production, 3. Penetration enhancers: They act by increasing corneal uptake by modifying the integrity of comeal epithelium. Chelating agents, preservatives, surfactants and bile salts were studied as possible penetration enhances. But the effort was diminished due to the local toxicity associated with enhancers12. Penetration enhancers have also been reported to reduce the drop size of conventional ophthalmic solutions especiallyif they do not elicit local irritation. 4. Prodrugs: Prodrugs enhance comeal drug permeability through modification of the hydrophilic or lipophilicity of the drug13. The method includes modification of chemical structure of the drug molecule, thus making it selective, site specific and a safe ocular drug delivery system. Drugs with increased penetrability through prodrug formulations are-epinehrine13, phenylephrine, timolol, pilocarpine14 and albuterol. 5. Cyclodextrins: Cyclodextrins act as carriers by keeping the hydrophobic drug molecules in solution and delivering them to the surface of the biological membrane, where the relatively lipophilic membrane has a much lower affinity for the hydrophilic eyclodextrin molecules WO therefore they remain in the aqueous vehicle system.Pages: 1 2 3 [4] 5 6 7 8 9 10 11 12 13 14
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