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Rapid Improvement in Function in Alzheimers After Enbrel Injection

Since 1998 etanercept(aka Enbrel), a potent TNF blocking drug has been approved for human use, for rheumatoid arthritis as the first official accepted indication. Etanercept is now being used for a numerous other diseases that involve excesss TNF activity. Etanercept hooks on to TNF-alpha and stops TNF-alpha receptors on many cell surfaces. This blocking effect reduces the inflammatory effects of excess TNF-alpha. Researchers and physicians currently have extensive experience using etanercept to treat a variety of inflammatory disorders where TNF-alpha over activity is believed to play a role. Diseases such as psoriasis and Crohn's disease in addition to rheumatoid arthritis are examples of diseases that etanercept is used. A recent fascinating study from The Department of Neurology, USC School of Medicine used injections of etanercept(Enbrel) in the posterior neck. This location of injection was used to improve delivery of the drug into the brain, where it was hoped that its anti-inflammatory activity would take effect. The study included 15 patients who were injected weekly for six months. Posterior neck injection of etanercept led to sustained cognitive improvement for these patients with Alzheimer's disease which ranged from mild to severe. Other recent studies have also supported the idea that TNF plays a major part in the brain inflammation of Alzheimer's disease. The study authors from Department of Neurology, USC School of Medicine noted an unexpected and dramatic clinical result (which recurred in the majority of the patients that were treated with etanercept ).

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