A REVIEW ON TOPICAL OPHTHALMIC DRUG DELIVERY SYSTEMS

RECENT ADVANCES   New ophthalmic delivery system includes ocular in­serts, collagen shields, ocular films, disposable contact lens and other Novel drug delivery systems like hiosomes40 and nanoparticles29. Newer trend is a combination of drug de­livery technologies for improving the therapeutic response of a non efficacious drug. This can give a superior dosage forms for topical ophthalmic application. SUMMARY   Among these drug delivery systems, only few products have been, commercialized. An ideal system should have effective drug concentration at the target tissue for a tended period of time with minimum systemic effect. Patient acceptance is very important for the design of any comfort­able ophthalmic drug delivery system. Major Improvements are required in each system like improvement in sustained drug release, large scale manufacturing and stability. Com­bination of drug delivery systems could open a new direc­tive for improving the therapeutic response of a non-effica­cious system. They can overcome the limitations and com­bine the advantages of different systems. REFERENCES Aggarwal, D. and Kaur, I.P. Int. J. Pharm., 2005, 290, 155. Bharath, C. and Hiremath. S-R., Pharmazie, 1999, 51, 55. Calvo, P., Vila-Jato, L. and Alanso, M.J.. Int. J. Pharm., 1997 153, 41. Daragour, S., U.S Patent No. 147, 647, 1992. Davios, Davies Clin, Exp, Pharmasol. Physiol., 90W. 27, 558, Deshpande S.G. and Shirolkar, S., J. Pharm. Pharmacol., 1989, 41,197. Durrani, A.M., Farr, S.J. and Kellaway. I.W.. J. Pharm. Pharmacol., 1995, 47, 581.

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