A REVIEW ON TOPICAL OPHTHALMIC DRUG DELIVERY SYSTEMS

A soluble insert containing gentamycin sulphate and dex­amethasone phosphate has been developed Pilocarpine Insert for glaucoma is also reported. But these systems have the draw back that that blur vision while the polymer is dissolving. Water soluble bioadhesive component in its formulation has been developed to decrease the risk of expulsion and ensure prolonged residence in the eye, com­bined with controlled drug release. They are bioadhesive ophthalmic drug inserts. A system based on gentamycin obtained by extrusion of a mixture of polymers, showing a release timer of about 72 h has been reported. Due to difficulty with self-insertion, foreign body sensation, only few insert products are listed and pharmaceutical manu­facturers are not actively developing inserts for commer­cialization. 11. Implantable systems:   The poly lactic acid and its copolymers with glycolic acid have been used extensively as implants. An ocular implant for delivering ganciclovir for the treatment of cy­tomegalovirus has also been developed37. This delivers drug directly to the retina for over 5 months. These systems are less popular as they require minor surgery. 12. Minidisc:   Minidisc is a controlled release monolithic matrix type device consisting of a contoured disc with a convex front and a concave back surface38. The principle component is A (1) bis (4-methacryloxybutyl)-polydimethyI siloxane. They can be made hydrophilic and hydrophobic to permit ex­tended release of bath water soluble and water insoluble drugs. 13. Soft contact lenses:   The most widely used Material is poly-2-hydrosyethylmethacrylate.

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