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A REVIEW ON TOPICAL OPHTHALMIC DRUG DELIVERY SYSTEMS

A REVIEW ON TOPICAL OPHTHALMIC DRUG DELIVERY SYSTEMS

Eye is unique and very precious organ. It is considered as window of the soul. We can enjoy and viewed the whole world only with this organ. There are many eye ailments which affect this organ and one can loss the eye sight also. Therefore many ophthalmic drug delivery systems are available. These are classified as conventional and newer drug delivery systems.

A REVIEW ON TOPICAL OPHTHALMIC DRUG DELIVERY SYSTEMS

Most commonly available ophthalmic preparations are eye drops and ointments. But these preparations when instilled into the cul-de-sac are rapidly drained away from the ocular cavity due to tear flow and lacrimal nasal drainage. Only a small amount is available for its therapeutic effect resulting in frequent dosing1.

A REVIEW ON TOPICAL OPHTHALMIC DRUG DELIVERY SYSTEMS

Thus inefficient drug delivery into the eye occurs due to rapid tear turn over, lacrimal. drainage and drug dilution by tears2. Topical administration for ocular therapeutics is ideal because of smaller doses required compared to the systemic use, its rapid onset of action and freedom from systemic toxicity Topically applied ocular drugs have to reach the inner parts of the eye and transcorneal penetration is believed to be the major route for drug absorption.

Corneal absorption is much slower process than elimination.

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